GRM4, glutamate metabotropic receptor 4, 2914

N. diseases: 54; N. variants: 5
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0242422
Disease: Parkinsonian Disorders
Parkinsonian Disorders 		0.010 Biomarker group BEFREE We studied whether a novel positive allosteric modulator of the metabotropic glutamate receptor 4, PXT002331 (foliglurax), could reduce parkinsonism in primate models. 30216534 2018
CUI: C1839730
Disease: Prieto X-linked mental retardation syndrome
Prieto X-linked mental retardation syndrome 		0.010 GeneticVariation disease BEFREE We hypothesized that PRS in this family was caused by (i) haploinsufficiency for BMPR1B or (ii) a gain of function mechanism mediated by the BMPR1B-GRM4 fusion gene. 28418932 2017
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.320 Biomarker disease BEFREE We conclude that at least one susceptibility locus for schizophrenia is located within or nearby GRM7, whereas GRM4 is unlikely to be a major susceptibility gene for schizophrenia in the Japanese population. 19351574 2009
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.320 Biomarker disease PSYGENET We conclude that at least one susceptibility locus for schizophrenia is located within or nearby GRM7, whereas GRM4 is unlikely to be a major susceptibility gene for schizophrenia in the Japanese population. 19351574 2009
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease 		0.060 AlteredExpression disease BEFREE We and others have used PAMs targeting mGlu4 to show that potentiation of receptor signaling induces antiparkinsonian activity in a variety of PD animal models, including haloperidol-induced catalepsy and 6-hydroxydopamine-induced lesion. 27441572 2016
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease 		0.060 Biomarker disease BEFREE We also provide an update on clinical trials evaluating mGluR5 or mGluR4 ligands in PD. 29625424 2018
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.320 Biomarker disease PSYGENET Thus, this study did not provide evidence for the contribution of the mGluR4 gene to schizophrenia in the Japanese. 11525421 2001
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.320 Biomarker disease BEFREE Thus, this study did not provide evidence for the contribution of the mGluR4 gene to schizophrenia in the Japanese. 11525421 2001
CUI: C0426980
Disease: Motor symptoms
Motor symptoms 		0.020 Biomarker phenotype BEFREE This work provides a demonstration that a positive allosteric modulator of metabotropic glutamate receptor 4 can alleviate the motor symptoms of PD and the motor complications induced by l-dopa in primates. 30216534 2018
CUI: C0007370
Disease: Catalepsy
Catalepsy 		0.010 AlteredExpression disease BEFREE This work led to the identification of compound 40, a potent and selective mGluR4 positive allosteric modulator (PAM) with good water solubility and demonstrating consistent activity across validated preclinical rodent models of PD motor symptoms after intraperitoneal administration: haloperidol-induced catalepsy in mouse and the rat 6-hydroxydopamine (6-OHDA) lesion model. 28902994 2017
CUI: C0426980
Disease: Motor symptoms
Motor symptoms 		0.020 AlteredExpression phenotype BEFREE This work led to the identification of compound 40, a potent and selective mGluR4 positive allosteric modulator (PAM) with good water solubility and demonstrating consistent activity across validated preclinical rodent models of PD motor symptoms after intraperitoneal administration: haloperidol-induced catalepsy in mouse and the rat 6-hydroxydopamine (6-OHDA) lesion model. 28902994 2017
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease 		0.060 AlteredExpression disease BEFREE This work led to the identification of compound 40, a potent and selective mGluR4 positive allosteric modulator (PAM) with good water solubility and demonstrating consistent activity across validated preclinical rodent models of PD motor symptoms after intraperitoneal administration: haloperidol-induced catalepsy in mouse and the rat 6-hydroxydopamine (6-OHDA) lesion model. 28902994 2017
CUI: C0021125
Disease: Impulsive Behavior
Impulsive Behavior 		0.010 Biomarker phenotype BEFREE These findings demonstrate that mGluR4s, in conjunction with D<sub>2</sub> receptors, affect motor- and choice-based measures of impulsivity, and therefore may be novel targets to modulate impulsive behaviour associated with a number of neuropsychiatric syndromes. 28487067 2017
CUI: C0025149
Disease: Medulloblastoma
Medulloblastoma 		0.020 Biomarker disease BEFREE These drugs appear to display pleiotropic effect on tumor cells, affecting proliferation, differentiation, and response to chemotherapy. mGlu1 and mGlu4 receptors could also be targeted by potential anticancer agents in the treatment of malignant gliomas and medulloblastoma, but extensive research is required for target validation. 29525720 2018
CUI: C0278510
Disease: Childhood Medulloblastoma
Childhood Medulloblastoma 		0.010 Biomarker disease BEFREE These drugs appear to display pleiotropic effect on tumor cells, affecting proliferation, differentiation, and response to chemotherapy. mGlu1 and mGlu4 receptors could also be targeted by potential anticancer agents in the treatment of malignant gliomas and medulloblastoma, but extensive research is required for target validation. 29525720 2018
CUI: C0278876
Disease: Adult Medulloblastoma
Adult Medulloblastoma 		0.010 Biomarker disease BEFREE These drugs appear to display pleiotropic effect on tumor cells, affecting proliferation, differentiation, and response to chemotherapy. mGlu1 and mGlu4 receptors could also be targeted by potential anticancer agents in the treatment of malignant gliomas and medulloblastoma, but extensive research is required for target validation. 29525720 2018
CUI: C0555198
Disease: Malignant Glioma
Malignant Glioma 		0.010 Biomarker disease BEFREE These drugs appear to display pleiotropic effect on tumor cells, affecting proliferation, differentiation, and response to chemotherapy. mGlu1 and mGlu4 receptors could also be targeted by potential anticancer agents in the treatment of malignant gliomas and medulloblastoma, but extensive research is required for target validation. 29525720 2018
CUI: C0025149
Disease: Medulloblastoma
Medulloblastoma 		0.020 Biomarker disease LHGDN These data suggest that mGlu4 receptor enhancers are promising drugs for the treatment of medulloblastomas. 16899734 2006
CUI: C0029463
Disease: Osteosarcoma
Osteosarcoma 		0.450 AlteredExpression disease BEFREE The results of Western blot and RT-PCR indicated a significantly increased expression level of mGluR4 gene and protein in osteosarcoma tissues compared with normal tissues. 24399291 2014
CUI: C0585442
Disease: Osteosarcoma of bone
Osteosarcoma of bone 		0.050 AlteredExpression disease BEFREE The results of Western blot and RT-PCR indicated a significantly increased expression level of mGluR4 gene and protein in osteosarcoma tissues compared with normal tissues. 24399291 2014
CUI: C1332986
Disease: Childhood Osteosarcoma
Childhood Osteosarcoma 		0.050 AlteredExpression disease BEFREE The results of Western blot and RT-PCR indicated a significantly increased expression level of mGluR4 gene and protein in osteosarcoma tissues compared with normal tissues. 24399291 2014
CUI: C0014070
Disease: Encephalomyelitis
Encephalomyelitis 		0.010 Biomarker disease BEFREE The protective effect of mGluR4 on EAE calls for testing GluR4 enhancers in MS patients. 28236206 2017
CUI: C0011570
Disease: Mental Depression
Mental Depression 		0.010 Biomarker disease BEFREE The poorly conserved miR-1202 is downregulated in depression and is negatively correlated with GRM4. 27792966 2017
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.010 Biomarker disease BEFREE The poorly conserved miR-1202 is downregulated in depression and is negatively correlated with GRM4. 27792966 2017
CUI: C0344315
Disease: Depressed mood
Depressed mood 		0.010 Biomarker phenotype BEFREE The poorly conserved miR-1202 is downregulated in depression and is negatively correlated with GRM4. 27792966 2017